Design and Implementation of a Distributed Middleware for Parallel Execution of Legacy Enterprise Applications

A typical enterprise uses a local area network of computers to perform its business. During the off-working hours, the computational capacities of these networked computers are underused or unused. In order to utilize this computational capacity an application has to be recoded to exploit concurrency inherent in a computation which is clearly not possible for legacy applications without any source code. This thesis presents the design an implementation of a distributed middleware which can automatically execute a legacy application on multiple networked computers by parallelizing it. This middleware runs multiple copies of the binary executable code in parallel on different hosts in the network. It wraps up the binary executable code of the legacy application in order to capture the kernel level data access system calls and perform them distributively over multiple computers in a safe and conflict free manner. The middleware also incorporates a dynamic scheduling technique to execute the target application in minimum time by scavenging the available CPU cycles of the hosts in the network. This dynamic scheduling also supports the CPU availability of the hosts to change over time and properly reschedule the replicas performing the computation to minimize the execution time. A prototype implementation of this middleware has been developed as a proof of concept of the design. This implementation has been evaluated with a few typical case studies and the test results confirm that the middleware works as expected

Ionospheric quasi-biennial oscillation of the TEC amplitude of the equatorial ionization anomaly crests from continuous GPS data in the Southeast Asian region

International audienceThe quasi-biennial oscillation (QBO) signals at two Equatorial ionization anomaly (EIA) crests of the ionosphere have been studied using the continuous GNSS network data in Vietnam and adjacent regions during the 2008- 2021 period. The monthly mean EIA crests amplitudes are calculated. The Lomb-Scargle periodogram method was applied to the residuals of the EIA crests magnitudes, DTEC, which are obtained from subtracting the fittings with solar index, F10.7. The Lomb-Scargle spectrum shows the quasi-biennial component in the residuals DTEC with the picks at 18, 25, and 29-30 months. The ionosphere QBO at two EIA crests was found out by the band-pass filter centered at 25 months with haft-power points at 17 and 33 months. The zonal wind data at 50 hPa (~ 20 km) of the tropical equatorial stratosphere is used as the stratosphere QBO (SQBO) to consider the relationship between the SQBO and the obtained ionosphere QBO. The direct comparison and the cross wavelet transform of the SQBO and ionosphere QBO data series show that during 2008-2009, the ionosphere QBO signal is low, the SQBO and ionosphere QBO are in phase during the 2010-2013 and 2018-2021 periods, but anti-phase during the 2014-2017 period. For the 2010-2013, 2014-2017 and 2018-2021 periods, the correlation coefficients are 0.623, 0.637, -0.646 in the northern crest, and 0.571, 0.53, -0.530 in the southern crest, respectively. Furthermore, we also observed that the SQBO and the ionosphere QBO signals were shortened during the 2015-2016 period, approximately 1.5 years. Previous studies showed that the ENSO (El Niño - Southern Oscillation) warm phase, also known as El-Niño existed during 2015-2016. The results of this study allow us to assume that the SQBO influences the ionosphere QBO. Our results show that the SQBO is the main factor affecting the ionospheric QBO at two EIA crests. However, the physical theoretical interpretation of the mechanisms of action is a challenge for scientists and requires further research

Prevalence and Virulence of Commensal Pseudomonas Aeruginosa Isolates from Healthy Individuals in Southern Vietnam (2018–2020)

Understanding the colonization of Pseudomonas aeruginosa (P. aeruginosa) in healthy humans is useful for future prevention and treatment of P. aeruginosa infection. This study aimed to investigate the prevalence and risk factors of of P. aeruginosa colonization in healthy humans. At the same time, the virulence of the isolated P. aeruginosa was also studied. In the study, 609 Vietnamese volunteers (310 females and 299 males, age range of 2 to 73 years), who had no acute infection or disease symptoms participated at the time of sample collection. Samples were taken from the throat, nostrils, and outer ears. P. aeruginosa was found in 19 participants (3.12%, 95% CI: 0.017–0.045), mainly from the throat (11/19, 57.89%). Participants with a history of sinusitis were 11.57 times more likely to be colonized with P. aeruginosa than participants without a history of sinusitis (OR: 11.57, 95% CI: 4.08–32.76, p-value P. aeruginosa colonization. Among 16 P. aeruginosa isolates used in virulence tests, 100% (16/16) were positive for the synthesis of biofilm, pyocyanin, and siderophores; 93.75% (15/16) isolates were positive for the synthesis of gelatinase and protease; and 50% (8/16) isolates were positive for lipase. There were no differences in the pattern and range of virulence factors of P. aeruginosa isolates taken from participants with and without sinusitis history. P. aeruginosa colonized 3.12% of participants, and its presence was associated with sinusitis history

Resveratrol suppressed lps-induced cox-2 VIA miR-146a-5p inhibition in raw246.7 cells

Trans-resveratrol (Res) is a well-known natural stilbene frequently found in grapes which have been reported to possess antioxidant, anti-cancer activities and inhibited COX-2 expression. MicroRNAs (miRNAs) are short endogenous non-coding RNAs involved in the regulation of mRNA stability and protein synthesis. In our research, resveratrol isolated from Vitis heyneana Roem. & Schult Vitis heyneana was observed to suppress lipopolysaccharides (LPS)-induced COX-2 expression in Raw264.7 cells in a dose dependent manner. Using qPCR it was revealed that LPS induced the expression of miR-25, miR- 125a, miR-125b, miR-146a-5p, miR-146a-3p and miR-455. However, we only observed miR-146a-5p expression significantly decreased in resveratrol compared to untreated-control group. In addition, resveratrol abrogated the effect of miR-146a-5p mimic induced-COX-2 expression in Raw264.7 cells. Taken together, this study demonstrated for the first time the involvement of miR-146a-5p in resveratrol inhibited LPS-induced COX-2 expression in Raw264.7 cells

Superspreading event of SARS-CoV-2 infection at a bar, Ho Chi Minh City, Vietnam

We report a superspreading event of severe acute respiratory syndrome coronavirus 2 infection initiated at a bar in Vietnam with evidence of symptomatic and asymptomatic transmission, based on ministry of health reports, patient interviews, and whole-genome sequence analysis. Crowds in enclosed indoor settings with poor ventilation may be considered at high risk for transmission